RNA Details
Disease Name
atrial fibrillation
Tissue
heart
RNA Symbol
mir-146b
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
dual-luciferase reporter assay; PCR
Target
TIMP4
Pathway
NA
PubMed ID
Title
Integrated analysis of microRNA and mRNA expression profiles in the left atrium of patients with non-valvular paroxysmal atrial fibrillation: Role of miR-146b-5p in atrial fibrosis
Year
2015
Function
"miR-146b-5p, matrix metallopeptidase 9, and collagen content were upregulated whereas TIMP-4 was downregulated in patients with atrial fibrillation,miR-146b-5p probably acts as an intracellular mediator in the maladaptive remodeling in atrial fibrosis."